Hernia Research Today is a free monthly online journal that collates and summarizes the latest research about Hernia, including details on hiatal, inguinal, umbilical, abdominal, treatment.

Pulmonary vascular remodeling.

Miniati D

Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco School of Medicine, San Francisco, California, USA. miniatid@surgery.ucsf.edu

The maladaptive response of the pulmonary vasculature that occurs in patients with congenital diaphragmatic hernia significantly impacts outcome. Muscularized distal pulmonary arterioles inhibit the ability of the neonate to adjust to extrauterine circulation, resulting in severe pulmonary hypertension. This review summarizes the current state of knowledge regarding normal and abnormal development of the lung vascular system and identifies current and potential therapies directed toward preserving or restoring proper pulmonary vascular function.

Published 27 April 2007 in Semin Pediatr Surg, 16(2): 80-7.
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