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A case of congenital diaphragmatic hernia with a hernia sac attached to the liver: hints for an early embryological insult.

Sharma S, Jain R, Singh MK, Gupta DK

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.

We describe here the unusual operative findings in a case of congenital diaphragmatic hernia (CDH). A neonate antenatally diagnosed as having CDH was operated via a left subcostal incision. The operative findings included a large central diaphragmatic defect of 5 x 5 cm, lined by a thick sac. The contents of the hernia included the stomach, spleen, and loops of the small and large intestine. The left side of the liver was thinned out and forming a part of the dome of the sac of the CDH. Vessels of the hepatic tissue were in continuity with the sac. There were scattered liver tissues forming cords in the sac lining. These findings were confirmed by histopathologic examinations. These findings have not been reported earlier in humans and might help to elucidate the embryology of the development of the diaphragm. Our findings suggest that this kind of defect occurs early in development, and we hypothesize that it is associated with a poorer prognosis.

Published 9 October 2007 in J Pediatr Surg, 42(10): 1761-3.
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